Early-onset generalized pustular psoriasis is representative of autoinflammatory keratinization diseases

Gene Mutation Analysis in a Korean Patient with Early-Onset and Recalcitrant Generalized Pustular Psoriasis

424 Ann Dermatol Received June 4, 2013, Revised July 5, 2013, Accepted for publication July 7, 2013 Corresponding author: Eun-So Lee, Department of Dermatology, Ajou University School of Medicine, 164 WorldCup-ro, Yeongtong-gu, Suwon 443-380, Korea. Tel: 82-31-219-5190, Fax: 82-31-219-5189, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons...

IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis.

Elderly-Onset Generalized Pustular Psoriasis without a Previous History of Psoriasis Vulgaris

Generalized pustular psoriasis (GPP) is characterized by sudden fever and extensive erythema with pustules and occurs in patients with or without preceding psoriasis vulgaris. We report an 83-year-old man showing irregularly shaped erythema with pustules on the trunk and extremities. He initially had no fever and came to our clinic a few days after the onset of the skin lesions because of high ...

Infliximab in recalcitrant generalized pustular arthropatic psoriasis.

Generalized pustular psoriasis is an unstable inflammatory type of psoriasis, with widespread areas of erythema and sterile pustules, associated with fever and systemic symptoms. Infliximab is a monoclonal antibody with anti-TNFalpha activity, approved for use in psoriasis. We describe a male patient with a long history of stable arthropathic psoriasis, hospitalized with a generalized pustular ...

Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine.

Two multigravidae aged 27 and 29 years, with previous uneventful pregnancies, second being psoriatic, reported at 24 and 28 weeks of pregnancies, with generalized pustular lesions. Laboratory findings, including serum calcium were normal. Ultrasonography showed normal fetal growth. Histopathology confirmed pustular psoriasis. Patients were put on cyclosporine 3 mg/ kg weight/ day after failure ...